Cell-Derived Microparticles: New Targets in the Therapeutic Management of Disease

Mary Bebawy1, Ariane Roseblade1, Frederick Luk1, Tristan Rawling1, Alison Ung2, Georges E. R. Grau3

1School of Pharmacy, Graduate School of Health, The University of Technology, Sydney, NSW, Australia
2School of Chemistry and Forensic Science, Faculty of Science, The University of Technology, Sydney, NSW, Australia
3Vascular Immunology Unit, Sydney Medical School and Bosch Institute, The University of Sydney, NSW, Australia

Abstract


Intercellular communication is essential to maintain vital physiological activities and to regulate the organism’s phenotype. There are a number of ways in which cells communicate with one another. This can occur via autocrine signaling, endocrine signaling or by the transfer of molecular mediators across gap junctions. More recently communication via microvesicular shedding has gained important recognition as a significant pathway by which cells can coordinate the spread and dominance of selective traits within a population. Through this communication apparatus, cells can now acquire and secure a survival advantage, particularly in the context of malignant disease. This review aims to highlight some of the functions and implications of microparticles in physiology of various disease states, and present a novel therapeutic strategy through the regulation of microparticle production.

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J Pharm Pharm Sci, 16 (2): 238-253, 2013

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